Importance sampling for Lambda-coalescents in the infinitely many sites model

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Importance sampling for Lambda-coalescents in the infinitely many sites model.

We present and discuss new importance sampling schemes for the approximate computation of the sample probability of observed genetic types in the infinitely many sites model from population genetics. More specifically, we extend the 'classical framework', where genealogies are assumed to be governed by Kingman's coalescent, to the more general class of Lambda-coalescents and develop further Hob...

متن کامل

Unrooted genealogical tree probabilities in the infinitely-many-sites model.

The infinitely-many-sites process is often used to model the sequence variability observed in samples of DNA sequences. Despite its popularity, the sampling theory of the process is rather poorly understood. We describe the tree structure underlying the model and show how this may be used to compute the probability of a sample of sequences. We show how to produce the unrooted genealogy from a s...

متن کامل

A population model for $\Lambda$-coalescents with neutral mutations

Bertoin and Le Gall [1] introduced a certain probability measure valued Markov process that describes the evolution of a population, such that a sample from this population would exhibit a genealogy given by the so-called Λ-coalescent, or coalescent with multiple collisions, introduced independently by Pitman [9] and Sagitov [10]. We show how this process can be extended to the case where linea...

متن کامل

Coalescents and Neutral Sampling

C a population that is maintained at 2N genes for a large number of generations. Assume that each gene in each generation has a unique parental gene, the parental gene is equally likely to be any of the genes in the preceding generation, and the choices of parents for different genes are independent. Then two genes in the same generation will have the same parent with probability 1/2N and will ...

متن کامل

Genotype imputation in a coalescent model with infinitely-many-sites mutation.

Empirical studies have identified population-genetic factors as important determinants of the properties of genotype-imputation accuracy in imputation-based disease association studies. Here, we develop a simple coalescent model of three sequences that we use to explore the theoretical basis for the influence of these factors on genotype-imputation accuracy, under the assumption of infinitely-m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Theoretical Population Biology

سال: 2011

ISSN: 0040-5809

DOI: 10.1016/j.tpb.2011.01.005